* Source: Survey conducted among small animal veterinarians who recommended animal supplements
Other Veterinary Products
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Denamarin Advanced and Denamarin
Liver Health Support for Dogs
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Denamarin® Chewable Tablets
The #1 veterinarian recommended liver support brand†
Denamarin is a supplement for dogs containing
S-Adenosylmethionine (SAMe) and silybin
Available in a 30 count size and a 75 count size for dogs of all sizes
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Denamarin® Tablets
The #1 veterinarian recommended liver support brand †
Denamarin is a supplement for dogs and cats containing
S-Adenosylmethionine (SAMe) and silybin
Available in sizes for cats & small dogs
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Denamarin® Advanced Tablets
The #1 veterinarian recommended liver support brand †
Denamarin® Advanced combines
S-Adenosylmethionine (SAMe) and Silybin for liver support and protection
Utilizes the latest SAMe innovation
Why use Denamarin® Advanced Tablets
Denamarin Advanced Chewable Tablets
The #1 veterinarian recommended liver support brand †
Latest SAMe Innovation
Why use Denamarin Advanced Formula
Proprietary NMXSS75A™ SAMe salt:
- Greater bioavailability than original Denamarin®
- Smaller chewable tablets for easy administration
- Wider dosing range per chewable tablet
- Scored for accurate administration
- More days of administration per bottle
- Less bitter tablets
Administration of Denamarin Advanced Chewable Tablets for Dogs
Denamarin® Advanced Chewable Tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. The number of chewable tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian.
Small to Medium Dog
S-Adenosylmethionine 120 mg and Silybin-phosphatidylcholine complex (SPC) 118 mg, providing 35 mg of Silybin A+B
Dog's Weight (lbs) Number of Tablets Per Day 7-14 1/4 15-25 1/2 26-50 1
Large Dog
S-Adenosylmethionine 215 mg and Silybin-phosphatidylcholine complex (SPC) 235 mg, providing 70 mg of Silybin A+B
Dog's Weight (lbs) Number of Tablets Per Day 51-85 1 86-130 1 ½ Over 130 2
* Source: Survey conducted among small animal veterinarians who recommended animal supplements
Other Veterinary Products
Veterinarian Portal
Denamarin®
Liver Health Support for Cats
-
Denamarin® Advanced Tablets
The #1 veterinarian recommended liver support brand†
Denamarin® Advanced combines
S-Adenosylmethionine (SAMe) and Silybin for liver support and protection.
Utilizes the latest SAMe innovation
Why use Denamarin® Advanced Tablets
- Denamarin® Advanced is our Advanced line that utilizes NMXSS75A™ S-Adenosylmethionine, a proprietary veterinary researched specification.
- Does not contain any dyes
- Smaller, easier to administer tablets
Administration of Denamarin® ADVANCED Tablets
Denamarin® Tablets
The #1 veterinarian recommended liver support brand †
Denamarin is a supplement for dogs and cats containing
Available in enteric-coated tablets for cats
Administration of Denamarin® for Cats
For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach. 1, 2 Denamarin for Cats and Small Dogs tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration.
Feline Denamarin Daily* Administration Guide
Denamarin For Cats
S-Adenosylmethionine 90 mg and Silybin-phosphatidylcholine complex (SPC) 31 mg, providing 9 mg of Silybin A+B
| Body Weight | Body Weight | Number of Tablets Per Day |
|---|---|---|
| Up to 12 lbs | Up to 5.5 kg | 1 |
| Over 12 lbs | Over 5.5 kg | 1 Twice Daily |
*The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.
Many pets are maintained long-term on every-other-day or every-third-day administration.
Storage
Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.
References
* Source: Survey conducted among small animal veterinarians who recommended animal supplements
Other Veterinary Products
Veterinarian Portal
ABOUT
DENAMARIN
How does Denamarin ® work?
When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly.
Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, 1, 2 an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death 3, 4 and may help cell repair and regeneration. 5
Denamarin also helps support your pet's liver through the administration of SILYBIN. SILYBIN is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.
While best known for supporting the liver in dogs and cats, research has shown that the S-Adenosylmethionine (SAMe) in Denamarin may help support cognitive function in dogs 6. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector. Denamarin also provides a bioavailable form of silybin which supports oxidative balance.
Denamarin has no known side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, watch for a reponse in your pet's attitude, appetite, and activity level.
Denamarin is available as enteric-coated tablets for dogs and cats and in tasty chewable tablets for dogs. Advanced technology in the exclusive NMXSS75® S-Adenosylmethionine found in the chewable formulation provides stability, eliminating the need for enteric coating or foil-on-foil blistering. The chewable tablets for dogs are tasty, single size and scored for easy administration. Additionally, the chewable tablets allow for quicker uptake of the SAMe and less variability between dogs when compared to enteric-coated tablets.
Denamarin is available from your veterinarian. Please consult your veterinarian to see if Denamarin is right for your pet.
A Denamarin Success Story
Denamarin for my Dachshund
"My beloved 13 year old dachshund had been acting very sluggish and tired for several months--I attributed it to the normal aging process. One day, I brought him to the vet after he had refused to move off of the couch and just lay there shaking for a few hours for no apparent reason. After a thorough examination, the vet determined that his liver enzymes were elevated and recommended Denamarin. Several months later, I am so happy to notice that his energy levels have not only returned, he is like a new dog. He has the same energy level he had when he was a younger dog. A follow up visit to the vet has confirmed that his liver enzyme levels have decreased and are close to the normal range. Thank you!"
* Source: Survey conducted among small animal veterinarians who recommended animal supplements
Other Veterinary Products
Veterinarian Portal
FAQs
Denamarin Frequently Asked Questions
* Source: Survey conducted among small animal veterinarians who recommended animal supplements
Other Veterinary Products
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Liver Product
Selector
What product is right for my pet?
Liver Health Supplements
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Denamarin
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Denosyl
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|---|---|---|---|---|---|
| Species | For Dogs | ||||
| For Cats | |||||
| Supplement Form | |||||
| Supplement Form | Enteric-coated Tablet | ||||
| Chewable Tablet | |||||
| Soft Chew | |||||
| Active Ingredients | |||||
| Active Ingredients |
SAMe
Increases levels of glutathione which is an important compound protecting
liver health.
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Silybin
The silybin found in Denamarin and Marin Plus for dogs is complexed with
phosphatidylcholine which has been shown to increase absorption 4x
in dogs compared to standardized milk thistle extracts.
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Vitamin E
An antioxidant that has been shown to help protect liver function.
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Zinc
Supplementation may be beneficial in dogs with long-term decreased liver
function as these dogs often have low liver zinc levels. Zinc participates
in many enzymatic reactions within the body, and any deficiency may
have harmful effects. Zinc is not in Marin for Cats as deficiencies
have not been noted in cats.
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Curcumin
Curcumin has been shown to inhibit several mediators, supporting a healthy
inflammatory response. It also helps increase production of glutathione,
the liver's main antioxidant and “detoxifier” and protects against
fibrotic changes in the liver.
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Medium Chain Triglyceride (MCT) Oil
In the liver, MCTs can be used for energy for metabolic reactions. MCTs
can also help reduce fat deposition, which may occur in the liver
secondary to compromise.
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| Possible Veterinarian Recommended Suggested Uses | |||||
| Possible Veterinarian Recommended Suggested Uses | For acute liver cases resulting in sharply elevated liver enzymes | ||||
| Acetaminophen toxicity | |||||
| For chronic liver cases | |||||
| When using long term therapies with possible hepatotoxic agents | |||||
| Possible Veterinarian Recommended Suggested Uses | |||||
| Additional Suggested Uses | When administration on an empty stomach is needed | ||||
| Administration with food is needed | |||||
| When zinc and/or Vitamin E may benefit | |||||
| When a more economical choice is preferred | |||||
| For brain health | |||||
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Liver Health Supplements
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Denamarin
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Denosyl
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* Source: Survey conducted among small animal veterinarians who recommended animal supplements